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Genetically-identical-twins-show-comparable-tau-PET-load-and-spatial-distribution-1.pdf
Preview of 12/01/2022
🔗 Source: amypad.eu
📊 Size: 200 KB
👤 Author: Knox, Sean
⬇️ Downloads: 37

Summary

Genetically identical twins show comparable tau PET load and spatial distribution, with similarities largely resulting from genetic factors and differences attributed to non-shared environmental factors. The study of 78 genetically identical twins (39 pairs, average age 73) found correlated [18F]flortaucipir BPND in entorhinal, neocortical, and global regions, but not in the temporal region. Twin-pairs had a more similar spatial [18F]flortaucipir distribution than non-twin pairs, and co-twins could be identified with 86% accuracy based on spatial distribution. Within-pair differences in [18F]flortaucipir BPND were associated with differences in depressive symptoms, physical activity, and social activity. The results highlight the importance of genetic factors in tau accumulation and spreading, and also suggest a role for environmental factors in Alzheimer's disease pathological processes.

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Genetically identical twins show comparable tau PET load and spatial distribution, with similarities largely resulting from genetic factors and differences...

Technical Information

  • File Format: PDF
  • File Size: 200 KB
  • Pages: 1
  • Language: EN
  • Author: Knox, Sean
  • Total Downloads: 37
  • Last Updated: 1 week ago

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