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🔗 Source: ima.org.il
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Vitamin A deficiency is associated with enhanced proliferation of bile duct epithelial cells in rats, as evidenced by increased numbers of ducts, aberrant extended ductal morphology, and elevated numbers of nuclei expressing the proliferation marker Ki67. The study found that vitamin A-deficient rats had up-regulated expression of the retinoid X receptor-alpha in the biliary epithelium after common bile duct ligation, but not in vitamin A-sufficient rats. The results suggest that deficiency of vitamin A may exacerbate cholestasis due to excessive intrahepatic bile duct proliferation.

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Vitamin A deficiency is associated with enhanced proliferation of bile duct epithelial cells in rats, as evidenced by increased numbers of ducts, aberrant...

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  • File Format: PDF
  • File Size: 1.15 MB
  • Pages: 5
  • Language: EN
  • Total Downloads: 111
  • Last Updated: 1 week ago

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