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🔗 Source: jnm.snmjournals.org
📊 Size: 603 KB
📄 Pages: 8 pages
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Summary

Lipidots, synthetic lipid nanoparticles, were characterized for in vivo stability, biodistribution, and pharmacokinetics. Triply labeled lipidots (55 nm diameter) were injected intravenously into mice, and their distribution was analyzed using radioactive and fluorescent tracers. Results showed a plasmatic half-life of approximately 30 minutes, with lipidots accumulating in the liver and surprisingly in steroid-rich organs (adrenals and ovaries), but not in the spleen. This distribution pattern is specific to lipidots and attributed to their nanometric size and composition, conferring a lipoprotein-like behavior. The affinity of lipidots for steroid hormone-rich areas is of interest for targeting drugs and contrast agents to lipoprotein-receptor-overexpressing cancer cells in hormone-dependent tumors.

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Description

Lipidots, synthetic lipid nanoparticles, were characterized for in vivo stability, biodistribution, and pharmacokinetics.

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  • File Format: PDF
  • File Size: 603 KB
  • Pages: 8
  • Language: EN
  • Total Downloads: 69
  • Last Updated: 6 hours ago

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