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Induced_expression_of_microsomal_STIBOROVA_Publishedonline12January2016_GOLD_VoR_CC_BY_.pdf
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Researchers investigated the effect of ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol on the expression of microsomal cytochrome b5 in rat livers, finding that the compounds induced cytochrome b5 mRNA and protein levels up to 11.7-fold and 7-fold, respectively. The induced cytochrome b5 contributed to the enhanced metabolism of these xenobiotics, with microsomes from exposed rats catalyzing their oxidation and DNA adduct formation more effectively than those from control rats.

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Researchers investigated the effect of ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol on the expression of microsomal cytochrome b5 in rat livers,...

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