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Oncogene.pdf

oncogene.pdf
Preview of Oncogene.pdf
🔗 Source: voices.uchicago.edu
📊 Size: 4.89 MB
👤 Author: Ningfei An
⬇️ Downloads: 126

Summary

Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells. CUX1 mutations are prevalent in myeloid neoplasms and often occur early in disease pathogenesis, carrying a poor prognosis. Combining CUX1 deficiency with oncogenic RAS mutations leads to the development of acute myeloid leukemia (AML) in mice, whereas either mutation alone does not. Oncogenic RAS increases self-renewal of CUX1-deficient hematopoietic stem/progenitor cells, and CUX1 knockdown amplifies RAS signaling. Double mutant cells are responsive to PIK3 or MEK inhibition, suggesting a potential therapy for malignancies with CUX1 inactivation.

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Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.

Technical Information

  • File Format: PDF
  • File Size: 4.89 MB
  • Pages: 13
  • Language: EN
  • Author: Ningfei An
  • Total Downloads: 126
  • Last Updated: 1 month ago

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