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Reviewer Report - James J. Driscoll.pdf

12885_2019_6185_ReviewerReport_V0_R2.pdf
Preview of Reviewer Report - James J. Driscoll
🔗 Source: static-content.springer.com
📊 Size: 65 KB
📄 Pages: 3 pages
⬇️ Downloads: 172

Summary

Semaan et al. report that TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model. The authors found that enzalutamide treatment is more effective in cells/tumors with TMPRSS2-ERG translocations, and that ERG expression status in tumors could help stratify patients for enzalutamide therapy. The study suggests that ERG transcription factor regulates androgen biosynthetic enzyme expression, and that knocking down ERG in VCaP cells leads to a lesser response to enzalutamide therapy. The reviewer agrees that the methods are appropriate, the work includes necessary controls, and the conclusions are adequately supported by the data.

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Description

Semaan et al. report that TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model.

Technical Information

  • File Format: PDF
  • File Size: 65 KB
  • Pages: 3
  • Language: EN
  • Total Downloads: 172
  • Last Updated: 2 weeks ago

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