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Predicted Structural Effect of the HGD gene Missense Variants_139M_new.pdf
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🔗 Source: hgddatabase.cvtisr.sk
📊 Size: 553 KB
👤 Author: dascher
⬇️ Downloads: 153

Summary

The HGD gene missense variants were assessed for their effects on molecular interactions, with 139 variants evaluated using mCSM and DUET to predict impact on protomer and hexamer thermal stability, and mCSM-PPI to predict effects on protomer interaction affinity. Variants were classified as destabilizing, marginally destabilizing, neutral, or stabilizing based on ΔΔG values. The analysis included distance to interface, active site Fe, and substrate, as well as Shannon entropy values and secondary structure assignments. The results showed various effects on protomer and hexamer stability, with some variants predicted to be highly destabilizing and others having minimal impact.

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The HGD gene missense variants were assessed for their effects on molecular interactions, with 139 variants evaluated using mCSM and DUET to predict impact on...

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  • File Format: PDF
  • File Size: 553 KB
  • Pages: 5
  • Language: EN
  • Author: dascher
  • Total Downloads: 153
  • Last Updated: 2 hours ago

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