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Alzheimer's Update.pdf

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Preview of Alzheimer's Update
🔗 Source: touchneurology.com
📊 Size: 176 KB
📄 Pages: 2 pages
⬇️ Downloads: 88

Summary

Martin R Farlow discusses treatment developments in Alzheimer's disease, citing failed phase III clinical trials and potential reasons, including adverse effects, late disease stage, and incorrect targeting of amyloid production. He notes promise in aducanumab, a monoclonal antibody targeting oligoclonal amyloid proteins, and a shift towards targeting earlier stages of the disease. Limitations of targeting amyloid-beta peptide include high doses causing microhemorrhage, disease stage, toxicities, and low antibody penetration into the central nervous system. Other therapeutic targets being investigated include microglia, inflammatory pathways, anti-tau antibodies, and tau metabolism. Aducanumab is currently the most promising agent in clinical development.

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Description

Martin R Farlow discusses treatment developments in Alzheimer's disease, citing failed phase III clinical trials and potential reasons, including adverse...

Technical Information

  • File Format: PDF
  • File Size: 176 KB
  • Pages: 2
  • Language: EN
  • Total Downloads: 88
  • Last Updated: 2 weeks ago

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This PDF document about Alzheimer's Update provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into Alzheimer's Update.

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