1. Cisplatin (順鉑):
- Administration: Intravenous injection
- Side effects: Nausea, vomiting, peripheral neuropathy, tinnitus, renal impairment, myelosuppression
- Precautions: Contraindicated in patients with severe platinum allergies, pregnancy, and breastfeeding. Monitor renal function and hydration.
2. Carboplatin (卡鉑):
- Administration: Intravenous injection
- Side effects: Nausea, vomiting, peripheral neuropathy, decreased appetite, myelosuppression, alopecia, skin rash
- Precautions: Contraindicated in patients with severe platinum allergies, pregnancy, and breastfeeding. Ensure adequate hydration to prevent renal damage.
3. Pemetrexed (愛寧達):
- Administration: Intravenous injection
- Side effects: Myelosuppression, anorexia, nausea, abnormal liver function, fatigue, neuropathy, mild alopecia
- Precautions: Supplement with folic acid and vitamin B12 starting 7 days before treatment and continue until 21 days after the last dose.
4. Gemcitabine (健擇):
- Administration: Intravenous injection
- Side effects: Nausea, vomiting, myelosuppression, alopecia, skin rash, dyspnea, edema, fever
- Precautions: Contraindicated in pregnancy and breastfeeding due to potential harm to the fetus or infant. Monitor for myelosuppression and take precautions against infection.
5. Paclitaxel (汰癌勝, 太平洋紫杉醇):
- Administration: Intravenous injection
- Side effects: Myelosuppression, nausea, vomiting, muscle pain, peripheral neuropathy, alopecia, edema
- Precautions: Monitor for myelosuppression and take precautions against infection. May cause cardiac arrhythmias and hypotension, requiring ECG monitoring.
6. Docetaxel (剋癌易, 歐洲紫杉醇):
- Administration: Intravenous injection
- Side effects: Weakness, stomatitis, nausea, vomiting, diarrhea, muscle pain, fluid retention, edema, alopecia, peripheral neuropathy
- Precautions: Monitor for myelosuppression and take precautions against infection. May cause allergic reactions, including angioedema, rash, flushing, fever, hypotension, bronchospasm, and dyspnea, requiring premedication with anti-allergic drugs.
7. Fluorouracil (5-FU, 好復):
- Administration: Intravenous injection
- Side effects: Stomatitis, esophagitis, diarrhea, decreased appetite, nausea, vomiting
- Precautions: Monitor liver function and maintain oral hygiene to prevent stomatitis.
8. Etoposide (滅必治):
- Administration: Intravenous injection, oral
- Side effects: Nausea, vomiting, diarrhea, alopecia, skin rash, elevated liver enzymes, peripheral neuropathy
- Precautions: Oral capsules should be taken with water on an empty stomach and stored at room temperature. Monitor for myelosuppression and take precautions against infection.
9. Topotecan (癌康定):
- Administration: Intravenous injection
- Side effects: Myelosuppression, nausea, vomiting, alopecia, allergic reactions, abdominal pain, fatigue
- Precautions: Monitor for interstitial pneumonia and myelosuppression, taking precautions against infection.
10. TS-1 (愛斯萬):
- Administration: Oral
- Side effects: Anorexia, nausea, vomiting, myelosuppression
- Precautions: Use with caution in patients with abnormal liver function. Monitor for myelosuppression and take precautions against infection.
11. Vinorelbine (溫諾平):
- Administration: Oral
- Side effects: Myelosuppression, peripheral neuropathy, fatigue, constipation, nausea, vomiting, alopecia
- Precautions: Store in a cool, dark place, swallow whole, and avoid chewing or breaking the capsule. Monitor for myelosuppression and take precautions against infection.
12. Uracil, Tegafur (友復):
- Administration: Oral
- Side effects: Stomatitis, vomiting, diarrhea, abdominal pain, fatigue, anorexia, skin rash, cardiac, hepatic, or renal dysfunction
- Precautions: Monitor liver function and watch for signs of diarrhea and dehydration, requiring fluid replacement and appropriate management.
