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Doxorubicin Effects.pdf

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Preview of Doxorubicin Effects
🔗 Source: gavinpublishers.com
📊 Size: 401 KB
📄 Pages: 10 pages
⬇️ Downloads: 138

Summary

Anthracyclines, effective chemotherapeutic agents, have limited use due to serious cardiac side effects, including irreversible and potentially fatal cardiac failure, related to cumulative dose and other factors. Exposure to anthracyclines results in genotoxic, energetic, and oxidative stress, closely related to the heart's dependence on oxidative phosphorylation and low defenses against reactive oxygen species. Cellular effects are documented by changes in enzymatic pathways within cardiomyocytes, often resulting in proteolysis, cellular damage, and apoptotic cell death, with necrosis and autophagy also involved. Most studies deal with in-vitro experiments and short-term murine models, lacking long-term animal models and clinical articles, with further exploration needed on the effects of anthracyclines on the extracellular matrix.

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Description

Anthracyclines, effective chemotherapeutic agents, have limited use due to serious cardiac side effects, including irreversible and potentially fatal cardiac...

Technical Information

  • File Format: PDF
  • File Size: 401 KB
  • Pages: 10
  • Language: EN
  • Total Downloads: 138
  • Last Updated: 2 months ago

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