FHR494911AuthorProof .pdf

FHR494911AuthorProof.pdf
Preview of FHR494911AuthorProof .pdf
🔗 Source: cris.unibo.it
📊 Size: 441 KB
📄 Pages: 12 pages
⬇️ Downloads: 34

Summary

Basic and Clinical Aspects, published in 2019, discusses the relationship between hyperandrogenism and severe insulin resistance (IR). Severe IR can be due to a defect in insulin signal transduction or adipose tissue dysfunction, with the latter being the most frequent form. Diagnosis is predominantly clinical, with biochemical biomarkers and gene screening used to corroborate the diagnosis. Biochemical indicators of severe IR include a fasting insulin value above 20.9 µU/mL and/or a peak insulin value on oral glucose tolerance testing above 209 µU/mL. Clinical aspects of severe IR states include acanthosis nigricans, dyslipidemia, hepatic steatosis, and early-onset hypertension. In females, severe IR states are often associated with clinical and/or biochemical hyperandrogenism and polycystic ovary syndrome (PCOS). Severe IR states can be classified into two categories: primary IR with a defect in insulin signal transduction, and secondary IR due to adipose tissue dysfunction.

Description

Basic and Clinical Aspects, published in 2019, discusses the relationship between hyperandrogenism and severe insulin resistance (IR).

Technical Information

  • File Format: PDF
  • File Size: 441 KB
  • Pages: 12
  • Language: EN
  • Total Downloads: 34
  • Last Updated: 1 month ago

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