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The GenoVA Study: Equitable Implementation Of A Pragmatic Randomized Trial Of Polygenic-risk Scoring In Primary Care.pdf

20231102_GenoVA_AJHG_Vassy_PRS-in-Primary-Care.pdf
Preview of The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care
🔗 Source: genomes2people.org
📊 Size: 2 MB
👤 Author: Jason L. Vassy
⬇️ Downloads: 73

Summary

The GenoVA Study is a pragmatic randomized trial assessing the clinical utility of polygenic-risk scoring in primary care, addressing challenges such as defining clinical utility, implementing in time-constrained settings, and countering potential healthcare disparities. The study focuses on six common diseases, including coronary artery disease, type 2 diabetes, and certain cancers, and uses a randomized controlled trial design to compare outcomes between PRS implementation and usual care. To promote health equity, the study has taken steps such as thoughtful handling of genetic ancestry and enhanced recruitment strategies, achieving proportional representation of underrepresented groups. The study's experience offers insights into evaluating the clinical utility of equitable PRS implementation in adult primary care.

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Description

The GenoVA Study is a pragmatic randomized trial assessing the clinical utility of polygenic-risk scoring in primary care, addressing challenges such as...

Technical Information

  • File Format: PDF
  • File Size: 2 MB
  • Pages: 12
  • Language: EN
  • Author: Jason L. Vassy
  • Total Downloads: 73
  • Last Updated: 3 hours ago

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