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Involvement Of Phospholipase C In The.pdf

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🔗 Source: scriptamedica.com
📊 Size: 315 KB
📄 Pages: 9 pages
⬇️ Downloads: 73

Summary

Norepinephrine (NE) mediates cardiomyocyte hypertrophy through the G protein coupled α1-adrenoceptor (α1-AR) and the activation of phosphoinositide-specific phospholipase C (PLC). The role of PLC isozymes in cardiac hypertrophy is highlighted, with a focus on the α1-AR-PLC-mediated hypertrophic signalling pathway. Specific activation of PLC isozymes is a primary signalling event in the α1-AR mediated response to NE and the initiation and progression of cardiac hypertrophy. PLC isozymes may serve as viable targets for the prevention of cardiac hypertrophy in patient populations at-risk for the development of heart failure.

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Description

Norepinephrine (NE) mediates cardiomyocyte hypertrophy through the G protein coupled α1-adrenoceptor (α1-AR) and the activation of phosphoinositide-specific...

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  • File Format: PDF
  • File Size: 315 KB
  • Pages: 9
  • Language: EN
  • Total Downloads: 73
  • Last Updated: 4 weeks ago

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