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Liver Cirrhosis Resolution.pdf

HGF-in-liver-VVVN.pdf
Preview of Liver Cirrhosis Resolution
🔗 Source: yhbpharma.com
📊 Size: 1.03 MB
👤 Author: Wook-Hwan Kim
⬇️ Downloads: 72

Summary

Hepatocyte growth factor (HGF) promotes resolution from liver cirrhosis by inhibiting growth and inducing apoptosis in portal myofibroblasts, which are key cells involved in liver fibrosis. HGF counteracts the effects of platelet-derived growth factor and induces c-jun N-terminal kinase phosphorylation, leading to apoptotic cell death in portal myofibroblasts. In a rat model of liver cirrhosis, administration of HGF suppressed proliferation and promoted apoptosis of α-smooth muscle actin-positive cells, resulting in reduced hepatic expressions of α-smooth muscle actin and histological resolution from liver cirrhosis.

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Description

Hepatocyte growth factor (HGF) promotes resolution from liver cirrhosis by inhibiting growth and inducing apoptosis in portal myofibroblasts, which are key...

Technical Information

  • File Format: PDF
  • File Size: 1.03 MB
  • Pages: 12
  • Language: EN
  • Author: Wook-Hwan Kim
  • Total Downloads: 72
  • Last Updated: 2 months ago

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This PDF document about Liver Cirrhosis Resolution provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into Liver Cirrhosis Resolution.

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