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Summary

Portulaca oleracea L. extract (POE) inhibits adipogenesis in 3T3-L1 adipocytes by regulating adipogenic transcription factors and enzymes, reducing triglyceride levels, and increasing glycerol release. POE decreases the expression of CCAAT/enhancer-binding protein α (C/EBPα), sterol regulatory element-binding protein 1c (SREBP-1c), and peroxisome proliferator-activated receptor γ (PPAR-γ), and inhibits the activity of acetyl-coenzyme A carboxylase (ACC) and fatty acid synthase (FAS). The phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) is increased, suppressing the expression of ACC and FAS by downregulating SREBP-1c. These results suggest that POE could potentially prevent obesity by inhibiting adipogenesis.

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Portulaca oleracea L.

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  • File Format: PDF
  • File Size: 832 KB
  • Pages: 6
  • Language: EN
  • Total Downloads: 35
  • Last Updated: 1 month ago

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