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Preview of Merlin Phosphatase Inhibition by CPI-17: Implications for Tumorigenic Transformation
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Merlin Phosphatase Inhibition by CPI-17: Implications for Tumorigenic Transformation (nature04856.pdf)

1.04 MBEN 4 pages
The study identifies MYPT-1–PP1d as the phosphatase activating merlin's tumor suppressor function, which is inhibited by CPI-17, leading to merlin phosphorylation and tumorigenic transformation. Elevated CPI-17 levels correlate with reduced merlin activity, Ras activation, and...
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