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Substitution Nuleophile

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Preview of Unified Mechanism of Proteolysis and Autocatalytic Activation in the 20S Proteasome
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Unified Mechanism of Proteolysis and Autocatalytic Activation in the 20S Proteasome (ncomms10900.pdf)

1.22 MBEva M HuberEN 10 pages
This article reveals a unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome, identifying Lys33 and Thr1 as key components of a catalytic triad, with Thr1 substitution inactivating the enzyme
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