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Corn is a rich source of nutritional compounds, including carbohydrates, proteins, vitamins, and minerals, and its various parts, such as seeds, leaves, corn silk, and stalk, are used as food, feed, and fuel. The phytochemical composition of corn includes polyphenols, phenolic acids, flavonoids, anthocyanins, carotenoids, and polysaccharides, which possess antioxidant potential and various biological activities, such as antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. Corn silk, in particular, is a good source of bioactive phytochemical compounds and has been traditionally used as a herbal remedy for various diseases, including hypercholesterolemia and urinary infections. The high antioxidant potential of corn makes it a potential ingredient for the management of oxidative stress and the treatment of various diseases.