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803931.pdf

803931.pdf
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🔗 Source: publications.rwth-aachen.de
📊 Size: 6.13 MB
👤 Author: Ayobahan, Uwa Steve
⬇️ Downloads: 80

Summary

This dissertation explores the use of proteomics to differentiate between endocrine disruption and hepatotoxicity in ecotoxicological testing, focusing on the development of novel endpoints to identify molecular mechanisms underlying adverse effects. The study used a fish short-term reproduction assay (FSTRA) with a hepatotoxic substance (acetaminophen) and an endocrine disrupting chemical (fadrozole) to monitor effects on zebrafish reproduction and identify candidate biomarkers for distinguishing between hepatotoxicity and endocrine-mediated toxicity.

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This dissertation explores the use of proteomics to differentiate between endocrine disruption and hepatotoxicity in ecotoxicological testing, focusing on the...

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  • File Format: PDF
  • File Size: 6.13 MB
  • Pages: 238
  • Language: EN
  • Author: Ayobahan, Uwa Steve
  • Total Downloads: 80
  • Last Updated: 4 weeks ago

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