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807445.pdf

807445.pdf
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🔗 Source: publications.rwth-aachen.de
📊 Size: 1.33 MB
👤 Author: Sofia Basova, Nathalie Wilke, Jan Christoph Koch, Aram Prokop, Albrecht Berkessel, Gabriele Pradel a
⬇️ Downloads: 168

Summary

Eleven organoarsenic compounds were synthesized and tested for their effect on the asexual blood stages and sexual transmission stages of the malaria parasite Plasmodium falciparum using in vitro assays. Five compounds showed antiplasmodial activities against the chloroquine-sensitive 3D7 strain, with IC50 values ranging between 1.52 and 8.64 µM. Three compounds also acted against the chloroquine-resistant Dd2 strain, with the most active compound As-8 exhibiting an IC50 of 0.35 µM. The compounds also showed significant inhibitory effects on the parasite sexual stages, with As-8 displaying the best gametocytocidal activity. No hemolytic and cytotoxic effects were observed for any of the compounds, suggesting that As-8 may represent a good lead for the design of novel organoarsenic drugs with combined antimalarial and transmission-blocking activities.

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Eleven organoarsenic compounds were synthesized and tested for their effect on the asexual blood stages and sexual transmission stages of the malaria parasite...

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  • File Format: PDF
  • File Size: 1.33 MB
  • Pages: 13
  • Language: EN
  • Author: Sofia Basova, Nathalie Wilke, Jan Christoph Koch, Aram Prokop, Albrecht Berkessel, Gabriele Pradel a
  • Total Downloads: 168
  • Last Updated: 3 weeks ago

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