[9].pdf

Goldenseal, berberine, and hydrastine are being reviewed for toxicological testing due to potential human exposure and lack of chronic or carcinogenicity data. Goldenseal is used to treat various disorders, and its products are available in health food stores and as ingredients in over-the-counter herbal supplements. Berberine and hydrastine have various uses, including as bitter tonics, antipyretics, and treatments for skin diseases and infections. Exposure to these compounds can occur orally, dermally, or through eye or vaginal application. Toxic effects in humans include convulsions, irritation, and respiratory failure, while animal studies have shown LD50 values for berberine and hydrastine, as well as effects on blood pressure, temperature, and behavior. No subchronic or chronic toxicity data are available for goldenseal or hydrastine, and conflicting information exists regarding the toxicity of hydrastine.