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Preview of Additional file 14: Table S13.

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👤 Author: Denise Sheer

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Summary

Researchers identified a tumor-specific hypomethylation signature in pilocytic astrocytomas, a type of pediatric low-grade astrocytoma, through DNA methylation analysis. The study found that most genes were hypomethylated in pilocytic astrocytomas, except for a few that were hypermethylated. The affected genes are involved in various cellular processes, including cell proliferation, differentiation, and transformation, as well as tumor suppression and oncogenesis. The genes highlighted in bold were hypermethylated in pilocytic astrocytomas, while the others were hypomethylated. The functions of these genes include ATP-binding cassette transporters, tumor suppressor roles, regulation of complement-mediated cell lysis, and signal transduction events. The study's findings may contribute to a better understanding of the molecular mechanisms underlying pilocytic astrocytomas and potentially inform the development of targeted therapies.

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Researchers identified a tumor-specific hypomethylation signature in pilocytic astrocytomas, a type of pediatric low-grade astrocytoma, through DNA methylation...

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File Format: PDF
File Size: 246 KB
Pages: 2
Language: EN
Author: Denise Sheer
Total Downloads: 47
Last Updated: 1 week ago

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