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Andrabi Et Al. 2018.pdf

andrabi2018.pdf
Preview of Andrabi et al. 2018
🔗 Source: corevih-bretagne.fr
📊 Size: 1021 KB
👤 Author: Raiees Andrabi
⬇️ Downloads: 89

Summary

A prophylactic HIV vaccine is crucial for controlling the pandemic, and its ability to elicit broadly neutralizing antibodies (bnAbs) is a key property. Current vaccine design approaches aim to trigger rare B cell precursors and steer affinity maturation toward bnAbs through a multi-stage, multi-component immunization strategy. This involves priming with bnAb precursor-targeting molecules and sequential or cocktail immunogen boosts to drive affinity maturation. Recent progress includes the development of native Env trimer immunogens, germline-targeting immunogens, and advances in animal models and technologies to analyze antibody responses. A multi-immunogen approach is necessary to induce neutralization breadth, and studies have shown that exposure to viral variation within a bnAb epitope drives antibody maturation toward neutralization breadth.

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A prophylactic HIV vaccine is crucial for controlling the pandemic, and its ability to elicit broadly neutralizing antibodies (bnAbs) is a key property.

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  • File Format: PDF
  • File Size: 1021 KB
  • Pages: 9
  • Language: EN
  • Author: Raiees Andrabi
  • Total Downloads: 89
  • Last Updated: 1 week ago

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