The annotation scheme for entities was derived in part from the Unified Medical Language System R (UMLS R) Semantic Groups, defining 135 categories of entities, including anatomical structures, biological processes, and clinical concepts. The scheme also included a set of predefined relations, such as "treatment of" and "cause of", to capture the relationships between entities. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation Tool (BRAT), which supports complex annotation schemes for entities and relations. The annotation scheme was designed to provide a broad coverage of the clinical domain, allowing for the annotation of medical events of interest mentioned in the clinical documents. The scheme included a set of guidelines for annotating entities and relations, which were extensively clarified and modified during the preliminary annotation phase. The guidelines were updated accordingly during the pilot annotation phase. Annotators were instructed to annotate entities and relations using the Brat Rapid Annotation
