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Cobalt And Cobalt Compounds That Release Cobalt Ions In Vivo.pdf

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Preview of Cobalt and cobalt compounds that release cobalt ions in vivo
🔗 Source: ntp.niehs.nih.gov
📊 Size: 540 KB
📄 Pages: 8 pages
⬇️ Downloads: 100

Summary

Cobalt and cobalt compounds that release cobalt ions in vivo are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data from studies on mechanisms of carcinogenesis. The release of cobalt ions in vivo is a key event for cobalt-induced carcinogenicity, and both water-soluble cobalt compounds and poorly water-soluble cobalt particles can release cobalt ions in vivo. Mechanistic data indicate that cobalt ions can cause cell death, DNA damage, and cancer through various modes of action, including inhibition of DNA repair, genotoxicity, generation of reactive oxygen species, and stabilization of hypoxia-inducible factor 1α.

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Description

Cobalt and cobalt compounds that release cobalt ions in vivo are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity...

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  • File Format: PDF
  • File Size: 540 KB
  • Pages: 8
  • Language: EN
  • Total Downloads: 100
  • Last Updated: 3 weeks ago

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