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Summary

Unsymmetrically N-substituted and N,N'-disubstituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-diones were synthesized using a new protocol, introducing modifications at the building block selection and post-cyclization stages, expanding structural diversity and potential applications. Novel tricyclic and pentacyclic scaffolds were obtained, and their structures were confirmed by single-crystal X-ray diffraction analysis. The cytotoxic effect of the synthesized compounds was determined, showing relatively weak activity, but the 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione framework may serve as a useful tool for designing novel bioactive molecules.

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Unsymmetrically N-substituted and N,N'-disubstituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-diones were synthesized using a new protocol, introducing...

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  • File Format: PDF
  • File Size: 3.22 MB
  • Pages: 24
  • Language: EN
  • Total Downloads: 98
  • Last Updated: 3 weeks ago

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