DiRex.pdf

struct1441.pdf
Preview of DiRex
🔗 Source: schroderlab.org
📊 Size: 1.46 MB
📄 Pages: 12 pages
⬇️ Downloads: 250

Summary

Structural studies of large proteins and protein assemblies are challenging due to often yielding only low-resolution or sparse data. A general geometry-based algorithm has been developed to efficiently sample conformational space under constraints imposed by low-resolution density maps. A deformable elastic network (DEN) is used to restrain the sampling to prior knowledge of an approximate structure, reducing overfitting, especially at low resolution. Cross-validation is used to optimally weight structural information and experimental data. The algorithm is robust and has a large radius of convergence, and the DEN restraints can enhance reciprocal space simulated annealing refinement.

Description

Structural studies of large proteins and protein assemblies are challenging due to often yielding only low-resolution or sparse data.

Technical Information

  • File Format: PDF
  • File Size: 1.46 MB
  • Pages: 12
  • Language: EN
  • Total Downloads: 250
  • Last Updated: 19 hours ago

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