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Simons Indoles_Revision2_CYP24.pdf
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🔗 Source: orca.cardiff.ac.uk
📊 Size: 1.2 MB
👤 Author: Steve Evans
⬇️ Downloads: 20

Summary

Novel styryl-indoles were synthesized and evaluated as inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1), with the imidazole styrylindoles showing potent inhibitory activity comparable to the standard ketoconazole. Computational studies identified key enzyme binding interactions, highlighting the importance of complete occupation of the vitamin D access tunnel for inhibitory activity.

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Description

Novel styryl-indoles were synthesized and evaluated as inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1), with the imidazole styrylindoles showing...

Technical Information

  • File Format: PDF
  • File Size: 1.2 MB
  • Pages: 45
  • Language: EN
  • Author: Steve Evans
  • Total Downloads: 20
  • Last Updated: 1 month ago

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