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inh_20201001_0021.pdf
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🔗 Source: inhalationmag.com
📊 Size: 205 KB
📄 Pages: 8 pages
⬇️ Downloads: 64

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Inhaled administration of drugs to animals in pharmaceutical research involves technical and logistical challenges. The selection of test species is based on guideline requirements, availability of historical baseline data, and biological relevance to humans. Rats are commonly used as the rodent species, while minipigs are considered as the non-rodent species due to European legislation and the UK's Animals (Scientific Procedures) Act. Inhalation exposure systems consist of apparatus to generate a test atmosphere and present it to animals, with configurations varying depending on the size of the test species. Snout-only inhalation exposure is most commonly used, reducing dermal exposure and oral ingestion. Test atmospheres can be classified according to the physical state of the constituent materials, and apparatus such as clinical nebulizers or ultrasonic nebulizers are used to generate reproducible test atmospheres.

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Inhaled administration of drugs to animals in pharmaceutical research involves technical and logistical challenges.

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  • File Format: PDF
  • File Size: 205 KB
  • Pages: 8
  • Language: EN
  • Total Downloads: 64
  • Last Updated: 5 hours ago

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