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Brain-morph.pdf
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🔗 Source: softmath.seas.harvard.edu
📊 Size: 3.14 MB
👤 Author: Tuomas Tallinen; Jun Young Chung; François Rousseau; Nadine Girard; Julien Lefèvre; L. Mahadevan
⬇️ Downloads: 79

Summary

Researchers studied the growth and form of cortical convolutions in the human brain, using magnetic resonance images to build a 3D-printed layered gel mimic of the developing smooth fetal brain. The outer layer swelled relative to the core when immersed in a solvent, mimicking cortical growth and leading to the formation of sulci and gyri similar to those in fetal brains. Numerical simulations of the brain model also produced characteristic patterns of convolutions, suggesting that the size, shape, placement, and orientation of the folds arise through mechanical instability modulated by early fetal brain geometry. The study supports the hypothesis that tangential expansion of the cortical layer relative to sublayers generates compressive stress, leading to the mechanical folding of the cortex.

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Researchers studied the growth and form of cortical convolutions in the human brain, using magnetic resonance images to build a 3D-printed layered gel mimic of...

Technical Information

  • File Format: PDF
  • File Size: 3.14 MB
  • Pages: 15
  • Language: EN
  • Author: Tuomas Tallinen; Jun Young Chung; François Rousseau; Nadine Girard; Julien Lefèvre; L. Mahadevan
  • Total Downloads: 79
  • Last Updated: 7 days ago

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