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2020-Reducing-the-Immunogenic-Potential-of-Wheat-Flour-Silencing-of-Alpha-Gliadin-Genes-in-a-U.S.-Wheat-Cultivar.pdf
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🔗 Source: celiacdiseasecenter.columbia.edu
📊 Size: 3.51 MB
👤 Author: Susan B. Altenbach
⬇️ Downloads: 135

Summary

Researchers used RNA interference to silence alpha gliadin genes in a US wheat cultivar to reduce the immunogenic potential of wheat flour, which contributes to celiac disease. The resulting transgenic lines had significantly reduced reactivity to antibodies from celiac disease patients, but also showed decreased dough strength. The study suggests it may be difficult to selectively silence specific genes in complex wheat protein families, but reducing immunogenic potential while retaining functional properties may be possible.

Description

Researchers used RNA interference to silence alpha gliadin genes in a US wheat cultivar to reduce the immunogenic potential of wheat flour, which contributes...

Technical Information

  • File Format: PDF
  • File Size: 3.51 MB
  • Pages: 15
  • Language: EN
  • Author: Susan B. Altenbach
  • Total Downloads: 135
  • Last Updated: 3 weeks ago

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