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12987_2021_Article_283.pdf
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🔗 Source: oro.open.ac.uk
📊 Size: 1.27 MB
👤 Author: Maxwell Eisenbaum
⬇️ Downloads: 205

Summary

Repetitive head trauma is associated with the accumulation of tau species in the brain, and research suggests that the cerebrovasculature plays a role in tau elimination. A study using a mouse model of repetitive mild traumatic brain injury (r-mTBI) found that tau elimination from the brain was reduced 12 months post-injury, possibly due to decreased caveolin-1 mediated tau efflux at the blood-brain barrier (BBB). The study also found that the upstream regulator of endothelial caveolin-1, Mfsd2a, was elevated in r-mTBI cerebrovessels, coinciding with decreased expression of cerebrovascular caveolin-1 in the chronic phase post-injury. Additionally, angiopoietin-1, a mural cell-derived protein, was secreted from r-mTBI cerebrovessels to a greater extent than from sham animals, which may downregulate caveolin-1 expression in brain endothelia, resulting in decreased tau elimination across the BBB.

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Repetitive head trauma is associated with the accumulation of tau species in the brain, and research suggests that the cerebrovasculature plays a role in tau...

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  • File Format: PDF
  • File Size: 1.27 MB
  • Pages: 13
  • Language: EN
  • Author: Maxwell Eisenbaum
  • Total Downloads: 205
  • Last Updated: 1 week ago

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