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Gigi_EMBO J_11_82_67_0.pdf
Preview of Embo Journal. 1 (11):1429-1437.
🔗 Source: weizmann.ac.il
📊 Size: 4.24 MB
📄 Pages: 9 pages
⬇️ Downloads: 91

Summary

A monoclonal antibody, KG 8.13, was derived from a mouse immunized with bovine epidermal prekeratin and characterized by its binding to cytoskeletal polypeptides and by immunofluorescence microscopy. This antibody binds to a determinant present in a large number of human cytokeratin polypeptides, including some of the 'basic cytokeratin subfamily' and a few acidic cytokeratins. It reacts specifically with a wide variety of epithelial tissues and cultured epithelial cells, and also reacts with corresponding cytokeratin polypeptides in a broad range of species, including man, cow, chick, and amphibia. The antibody has limited reactivity with rodent cytokeratins. Its value for the immunohistochemical identification of epithelia and carcinomas is discussed.

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Description

A monoclonal antibody, KG 8.13, was derived from a mouse immunized with bovine epidermal prekeratin and characterized by its binding to cytoskeletal...

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  • Pages: 9
  • Language: EN
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