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The Evolving Role Of Investigative Toxicology In The Pharmaceutical Industry.pdf

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📊 Size: 1.68 MB
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Summary

The role of investigative toxicology in the pharmaceutical industry is evolving, with a shift from descriptive to mechanistic approaches, enabling better understanding of toxicity mechanisms and species relevance. Technological advances, such as induced pluripotent stem cells, 3D tissue models, and microphysiological systems, support the development of safety biomarkers and prediction of safety events. A tiered approach is adopted, employing in silico, biochemical, cellular in vitro assays, and in vivo safety experiments to identify and mitigate hazards. The goal is to increase the likelihood of success by optimizing the safety dimension of drug design and candidate selection, ultimately reducing safety-related attrition in drug development.

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The role of investigative toxicology in the pharmaceutical industry is evolving, with a shift from descriptive to mechanistic approaches, enabling better...

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  • File Format: PDF
  • File Size: 1.68 MB
  • Pages: 19
  • Language: EN
  • Total Downloads: 86
  • Last Updated: 1 week ago

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