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Fcell-08-00317.pdf

fcell-08-00317.pdf
Preview of fcell-08-00317.pdf
🔗 Source: repository.uel.ac.uk
📊 Size: 2.48 MB
👤 Author: Lesley Ann Smyth
⬇️ Downloads: 89

Summary

Regulatory T cells (Tregs) produce small extracellular vesicles (EVs) that can inhibit the proliferation of effector T cells and modify their cytokine production, increasing IL-4 and IL-10 while decreasing IL-6, IL-2, and IFNγ. MicroRNAs in Treg EVs are linked to these changes. In a humanized mouse skin transplant model, human Treg-derived EVs reduced alloimmune-mediated skin tissue damage by limiting immune cell infiltration, suggesting a potential cell-free therapy to promote transplant survival.

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Regulatory T cells (Tregs) produce small extracellular vesicles (EVs) that can inhibit the proliferation of effector T cells and modify their cytokine...

Technical Information

  • File Format: PDF
  • File Size: 2.48 MB
  • Pages: 14
  • Language: EN
  • Author: Lesley Ann Smyth
  • Total Downloads: 89
  • Last Updated: 3 weeks ago

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