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🔗 Source: beilstein-journals.org
📊 Size: 1.3 MB
👤 Author: Magnus Rueping, Boris J Nachtsheim
⬇️ Downloads: 65

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The development of efficient Friedel-Crafts alkylations using catalytic amounts of a Lewis acid has gained attention over the last decade, offering a more environmentally friendly alternative to classical conditions that require toxic benzyl halides and stoichiometric amounts of a Lewis acid. New catalytic approaches allow the use of benzyl-, propargyl-, and allyl alcohols, or styrenes, as alkylating reagents, producing a wide range of products with low catalyst loadings. This review highlights the progress made in Friedel-Crafts alkylations, including the use of environmentally benign substrates and the development of diastereoselective and enantioselective Friedel-Crafts-type alkylations.

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The development of efficient Friedel-Crafts alkylations using catalytic amounts of a Lewis acid has gained attention over the last decade, offering a more...

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  • File Format: PDF
  • File Size: 1.3 MB
  • Pages: 24
  • Language: EN
  • Author: Magnus Rueping, Boris J Nachtsheim
  • Total Downloads: 65
  • Last Updated: 6 hours ago

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