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Chiki_Mutant_Exon1_Huntingtin Aggregation-Int-ed.pdf
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🔗 Source: discovery.ucl.ac.uk
📊 Size: 373 KB
👤 Author: Domenico Sanfelice
⬇️ Downloads: 208

Summary

Researchers investigated the effects of lysine acetylation and phosphorylation on the structure and aggregation of mutant huntingtin exon1 (Httex1), finding that phosphorylation at T3 stabilizes the α-helical conformation and inhibits aggregation, while acetylation at K6 reverses this inhibitory effect, suggesting crosstalk between different post-translational modifications regulates Httex1 aggregation and function.

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Description

Researchers investigated the effects of lysine acetylation and phosphorylation on the structure and aggregation of mutant huntingtin exon1 (Httex1), finding...

Technical Information

  • File Format: PDF
  • File Size: 373 KB
  • Pages: 8
  • Language: EN
  • Author: Domenico Sanfelice
  • Total Downloads: 208
  • Last Updated: 1 week ago

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