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Verschoor_etal_SR_Phosphoprotein_enriched_in_VOR.pdf
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📊 Size: 5.87 MB
👤 Author: Pola J. Verschoor
⬇️ Downloads: 128

Summary

Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion, and decreasing its expression increases lipid sequestration in adipose tissue, protecting other tissues in obesity and improving metabolic health. PEA-15−/− mice on a high-fat diet developed increased body weight and white adipose tissue expansion, but exhibited improved insulin sensitivity, lower hepatic weight, and decreased serum triglycerides. Crossing PEA-15−/− mice with ApoE−/− mice on a high-fat diet protected them from atherosclerosis and hepatic lipid accumulation, despite increased adiposity.

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Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion, and decreasing its expression increases lipid sequestration in...

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  • File Format: PDF
  • File Size: 5.87 MB
  • Pages: 14
  • Language: EN
  • Author: Pola J. Verschoor
  • Total Downloads: 128
  • Last Updated: 5 hours ago

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