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2040-2384-2-26.pdf
Preview of http://www.biomedcen tral.com/content/pdf /2040-2384-2-26.pdf
🔗 Source: biomedcentral.com
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📄 Pages: 10 pages
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Summary

Angiogenesis, a form of neovascularization, plays a crucial role in various pathological conditions, including stroke, and is closely related to neuroregeneration. However, experimental data have largely ignored the age criterion, which is important as angiogenesis differs between young and old subjects. The dynamics of angiogenesis are age-dependent, and extrapolating data from young subjects or in vitro studies to old-age patients may lead to inaccurate conclusions. This review highlights the key features of brain senescence, including morphological and functional changes related to the brain parenchyma, vascular network, and blood flow, which influence post-stroke angiogenesis. The review also describes the relationship between post-stroke angiogenesis, neuroregeneration, and modulation by vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF-1) in old-age subjects.

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Angiogenesis, a form of neovascularization, plays a crucial role in various pathological conditions, including stroke, and is closely related to...

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  • Pages: 10
  • Language: EN
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