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Immunogenicity Of ADCs.pdf

12248_2014_Article_9684.pdf
Preview of Immunogenicity of ADCs
🔗 Source: ncbi.nlm.nih.gov
📊 Size: 256 KB
📄 Pages: 9 pages
⬇️ Downloads: 76

Summary

Immunogenicity of antibody-drug conjugates (ADCs) is a complex issue due to their unique structural components, which may contribute to additional complexities in immunologic responses and bioanalytical methods. ADCs have a protein component, a linker, and a small-molecule drug, and anti-drug antibodies (ADAs) may develop against any of these components. The evaluation of a potential humoral response against an ADC is more complex than for monoclonal antibody (mAb) therapeutics, and the consequences of an ADA response may differ. A thorough risk assessment is necessary to develop immunogenicity monitoring strategies, considering factors such as the probability of the biotherapeutic to elicit an immunogenic response and the severity of potential consequences.

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Description

Immunogenicity of antibody-drug conjugates (ADCs) is a complex issue due to their unique structural components, which may contribute to additional complexities...

Technical Information

  • File Format: PDF
  • File Size: 256 KB
  • Pages: 9
  • Language: EN
  • Total Downloads: 76
  • Last Updated: 1 week ago

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