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🔗 Source: resistancecontrol.info
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Summary

Next-generation sequencing (NGS) has transformed the analysis of bacterial genomes and complex bacterial communities, enabling the identification of known resistance genes and prediction of novel ones, which opens new perspectives in antimicrobial resistance (AMR) surveillance, risk assessment, and understanding of AMR dynamics. NGS allows for the sequencing of bacterial genomes and exploration of complex mixtures of species, such as the human microbiota or environmental samples. The technology has improved significantly over the last decade, with major advancements in sequencing, bioinformatic tools, and resources. Current challenges include the development of a standardized and curated database for ARGs and the need for high-throughput biological validation of new ARGs. Various databases, such as CARD and ResFinder, and bioinformatic tools, like Bowtie2 and BWA, are available for analyzing NGS data and identifying ARGs.

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Next-generation sequencing (NGS) has transformed the analysis of bacterial genomes and complex bacterial communities, enabling the identification of known...

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  • File Format: PDF
  • File Size: 233 KB
  • Pages: 6
  • Language: EN
  • Total Downloads: 94
  • Last Updated: 7 days ago

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