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Neurotransmitter Balance.pdf

6512_cz_Ovsepian BACE1.pdf
Preview of Neurotransmitter Balance
🔗 Source: hoschl.cz
📊 Size: 1.62 MB
👤 Author: Saak V. Ovsepian, Jiri Horacek, Valerie B. O’Leary, and Cyril Hoschl
⬇️ Downloads: 167

Summary

BACE1 is a rate-limiting enzyme in the production of amyloid beta-peptide (Aβ) in Alzheimer's disease (AD), and its inhibition is a promising therapeutic target for cognitive decline and amyloid pathology. However, changes in BACE1 activity have also been linked to noncognitive neuropsychiatric symptoms and impairments of circadian rhythms, suggesting a complex role in AD pathology. The enzyme plays a crucial role in maintaining physiological Aβ levels, and its dysregulation can lead to cognitive impairments and synaptic dysfunctions. While BACE1 inhibition has shown promise in reducing Aβ levels, it may also have adverse effects on mental health, highlighting the need for further mechanistic and translational studies to develop effective therapeutic strategies.

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Description

BACE1 is a rate-limiting enzyme in the production of amyloid beta-peptide (Aβ) in Alzheimer's disease (AD), and its inhibition is a promising therapeutic...

Technical Information

  • File Format: PDF
  • File Size: 1.62 MB
  • Pages: 13
  • Language: EN
  • Author: Saak V. Ovsepian, Jiri Horacek, Valerie B. O’Leary, and Cyril Hoschl
  • Total Downloads: 167
  • Last Updated: 1 week ago

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This PDF document about Neurotransmitter Balance provides comprehensive information and guidance. Whether you're a beginner or advanced user, this resource offers valuable insights into Neurotransmitter Balance.

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