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🔗 Source: neuro.wisc.edu
📊 Size: 5.01 MB
👤 Author: Yu Guo
⬇️ Downloads: 67

Summary

Researchers found that fragile X syndrome (FXS) and autism spectrum disorder (ASD) are linked to elevated levels of microtubule-associated protein 1B (MAP1B), a target of fragile X messenger ribonucleoprotein 1 (FMRP). FMRP deficiency leads to increased MAP1B, impairing neuronal development and social behaviors in humans and mice. Elevated MAP1B sequesters autophagy components, reducing autophagosome formation, and its reduction or autophagy activation rescues neuronal deficits in FXS and ASD patient-derived neurons.

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Researchers found that fragile X syndrome (FXS) and autism spectrum disorder (ASD) are linked to elevated levels of microtubule-associated protein 1B (MAP1B),...

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  • File Format: PDF
  • File Size: 5.01 MB
  • Pages: 23
  • Language: EN
  • Author: Yu Guo
  • Total Downloads: 67
  • Last Updated: 4 weeks ago

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