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🔗 Source: edoc.ub.uni-muenchen.de
📊 Size: 4.68 MB
👤 Author: Birgit Halbgewachs
⬇️ Downloads: 17

Summary

Die vorliegende Dissertation beschäftigt sich mit der Rolle des Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) als prometastatischer Faktor. Es wurde untersucht, wie TIMP-1 die Metastasierung von Tumoren beeinflusst und welche molekularen Mechanismen dabei eine Rolle spielen. Die Ergebnisse zeigen, dass TIMP-1 die Expression von Hypoxia-inducible Factor-1α (HIF-1α) in Tumorzellen induziert, was wiederum die Invasivität und Metastasierung von Tumoren fördert. Darüber hinaus wurde festgestellt, dass TIMP-1 die Infiltration von Neutrophilen Granulozyten in die Leber und ihre Migration in vitro verstärkt. Die Depletion von Neutrophilen Granulozyten reduzierte die TIMP-1-induzierte Metastasierung. Die Ergebnisse deuten darauf hin, dass TIMP-1 eine wichtige Rolle bei der Metastasierung von Tumoren spielt und dass HIF-1α und Neutrophile Granulozyten wichtige Mediatoren dieser Wirkung sind.

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Description

Die vorliegende Dissertation beschäftigt sich mit der Rolle des Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) als prometastatischer Faktor.

Technical Information

  • File Format: PDF
  • File Size: 4.68 MB
  • Pages: 125
  • Language: DE
  • Author: Birgit Halbgewachs
  • Total Downloads: 17
  • Last Updated: 2 months ago

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