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🔗 Source: naviauxlab.ucsd.edu
📊 Size: 1.06 MB
👤 Author: Robert K. Naviaux
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Summary

The cell danger response (CDR) is a metabolic response that protects cells and hosts from harm, triggered by encounters with chemical, physical, or biological threats. It produces a cascade of changes in cellular electron flow, oxygen consumption, redox, and bioenergetics, and is sustained by purinergic signaling. The CDR is coordinated in the brain via chemosensory integration of whole body and microbiome metabolism, and its abnormal persistence leads to altered organ function and behavior, resulting in chronic disease. The CDR is linked to various disorders, including autism, ADHD, asthma, and autoimmune diseases. Mitochondria play a key role in sensing threats and regulating the CDR, and small molecule nutrients and metabolites are the prime movers of the response.

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The cell danger response (CDR) is a metabolic response that protects cells and hosts from harm, triggered by encounters with chemical, physical, or biological...

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  • File Format: PDF
  • File Size: 1.06 MB
  • Pages: 11
  • Language: EN
  • Author: Robert K. Naviaux
  • Total Downloads: 96
  • Last Updated: 3 hours ago

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