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BioChem_2015_87_1_7.pdf
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🔗 Source: jnas.nbuv.gov.ua
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📄 Pages: 9 pages
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Summary

Novel non-peptidic furin inhibitors with inhibitory constants (Ki) of 0.74-1.54 μM were synthesized by interacting aminoguanidine hydrocarbonate with diaryldicarbaldehydes. Docking studies showed these inhibitors interact with subsites S1 and S4 of the enzyme, similar to the position of a co-crystallized ligand. The inhibitors are bisamidinohydrazones with varying linkers, and their synthesis and biological evaluation are described. Furin is a promising target for developing new medications to battle various human illnesses, including cancer and cardiovascular pathologies.

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Novel non-peptidic furin inhibitors with inhibitory constants (Ki) of 0.74-1.54 μM were synthesized by interacting aminoguanidine hydrocarbonate with...

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  • File Format: PDF
  • File Size: 2.25 MB
  • Pages: 9
  • Language: EN
  • Total Downloads: 68
  • Last Updated: 6 days ago

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