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🔗 Source: nature.com
📊 Size: 13.15 MB
👤 Author: Hanbin Jeong
⬇️ Downloads: 63

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Researchers report the structure of the native TMC-1 mechanosensory transduction complex from Caenorhabditis elegans using single-particle cryo-electron microscopy. The complex is a two-fold symmetric dimer composed of two copies each of the pore-forming TMC-1 subunit, the calcium-binding protein CALM-1, and the transmembrane inner ear protein TMIE. CALM-1 makes extensive contacts with the cytoplasmic face of the TMC-1 subunits, while TMIE subunits reside on the periphery of the complex. The structure suggests crucial roles for lipid-protein interactions in the mechanism of mechanical force transduction to ion channel gating, shedding light on the molecular composition and mechanism of the mechanosensory transduction complex, which is essential for hearing and balance in mammals.

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Researchers report the structure of the native TMC-1 mechanosensory transduction complex from Caenorhabditis elegans using single-particle cryo-electron...

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  • File Format: PDF
  • File Size: 13.15 MB
  • Pages: 27
  • Language: EN
  • Author: Hanbin Jeong
  • Total Downloads: 63
  • Last Updated: 2 hours ago

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