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🔗 Source: francis-press.com
📊 Size: 173 KB
👤 Author: 微软中国
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Summary

Research progress in antigen synthesis has been applied in various fields, including food, drug, and environmental protection, achieving ideal detection results. Artificial antigens are prepared by chemically synthesizing or genetically engineering a known cluster of chemical determinants. The synthesis of efficient artificial antigens is crucial and involves designing and synthesizing small molecular haptens, selecting carriers, coupling haptens and carriers, and purifying and identifying the resulting antigens. Haptens are substances that can only react with antibodies but not induce antibody production, and their design should retain characteristic groups of the tested object to ensure specific immune reactions. Carriers, such as bovine serum protein (BSA), play a crucial role in inducing immune reactions, and coupling methods, including carbodiimide and glutaraldehyde methods, are used to form artificial antigens. The introduction of spacer arms can increase the recognition of haptens by the immune system, and various coupling methods are used depending on the hapten groups, such as carboxylic, amino, and hydroxyl groups.

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Research progress in antigen synthesis has been applied in various fields, including food, drug, and environmental protection, achieving ideal detection...

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  • File Format: PDF
  • File Size: 173 KB
  • Pages: 5
  • Language: EN
  • Author: 微软中国
  • Total Downloads: 81
  • Last Updated: 4 hours ago

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