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Summary

Depletion of the m6A demethylases FTO and ALKBH5 impairs growth and metastatic capacity through EMT phenotype change in clear cell renal cell carcinoma. Knockdown of FTO and ALKBH5 in renal cancer cell lines resulted in decreased proliferation and motility, and downregulation of Vimentin (VIM), indicating an EMT switch. This suggests that FTO and ALKBH5 play a role in the carcinogenesis of renal cell carcinoma, and their inhibition may be a potential therapeutic strategy.

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Depletion of the m6A demethylases FTO and ALKBH5 impairs growth and metastatic capacity through EMT phenotype change in clear cell renal cell carcinoma.

Technical Information

  • File Format: PDF
  • File Size: 1.96 MB
  • Pages: 14
  • Language: EN
  • Total Downloads: 44
  • Last Updated: 3 hours ago

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