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GalkinBrandt_2005_J.Biol_.Chem_.pdf
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🔗 Source: mitolab.org
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Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica was investigated. Isolated complex I formed superoxide at a rate of 0.15% of the catalytic turnover rate, and this production was not inhibited by ubiquinone analogous inhibitors. The results suggest that oxygen accepts electrons from FMNH2 or FMN semiquinone, either directly or via hydrophilic ubiquinone derivatives, and that the terminal iron-sulfur cluster N2 is not involved in superoxide production.

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Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica was investigated.

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  • File Format: PDF
  • File Size: 140 KB
  • Pages: 7
  • Language: EN
  • Total Downloads: 45
  • Last Updated: 1 month ago

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